![]() ![]() In literature, several design methods for TPMS scaffolds have been developed, which considered some of the important tissue-specific requirements, such as porosity, Young's modulus, and pore size. TPMS scaffolds offer several advantages, which include a high surface area to volume ratio, less stress concentration, and increased permeability compared to the traditional lattice structures, thereby aiding in better cell adhesion, migration, and proliferation. Recently, triply periodic minimal surfaces (TPMSs) have attracted the attention of tissue engineering scientists for fabrication of biomimetic porous scaffolds. N2 - Biomimetic scaffold design is gaining attention in the field of tissue engineering lately. T2 - An optimization approach toward biomimetic scaffold designĬopyright 2021 Elsevier B.V., All rights reserved. T1 - Triply periodic minimal surfaces sheet scaffolds for tissue engineering applications The versatility of the proposed design method is demonstrated by three different applications, namely, tissuespecific scaffolds, scaffolds for stem cell differentiation, and functionally graded scaffolds with biomimetic functional gradients.", Three TPMSs, namely, the primitive (P), gyroid (G), and diamond (D) surfaces, with cubic symmetry are considered. In this work, we develop a design method for TPMS sheet scaffolds, which is able to satisfy multiple requirements including the porosity, Young's modulus, and pore size, based on a parametric optimization approach. However, only one of the requirements of a tissue engineering scaffold was investigated in these studies, and not all of the requirements were satisfied simultaneously. ![]() The versatility of the proposed design method is demonstrated by three different applications, namely, tissuespecific scaffolds, scaffolds for stem cell differentiation, and functionally graded scaffolds with biomimetic functional gradients.Ībstract = "Biomimetic scaffold design is gaining attention in the field of tissue engineering lately. Biomimetic scaffold design is gaining attention in the field of tissue engineering lately.
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